The International Space Station's (ISS) Expedition 45 begins with the scheduled undocking of Soyuz TMA-16M in October 2015. New crew members will arrive shortly thereafter on Soyuz TMA-17M.

ISS Expedition 45 will be commanded by NASA astronaut Scott Kelly. His crewmates, all flight engineers, include: Roscosmos cosmonauts Mikhail Korniyenko, Oleg Kononenko and Sergey Volkov, NASA astronaut Kjell Lindgren and Japan Aerospace Exploration Agency (JAXA) astronaut Kimiya Yui.
The Expedition 45 patch was designed by Kjell Lindgren working with artist Blake Dumesnil.
